Spider Control in Greenville South Carolina

Keep Your Home or Business Safe and Spider-Free

Finding spiders inside your home or business can be unsettling — especially when they start appearing in corners, basements, or around outdoor lights. At Pest Rx, we provide professional spider control services across Upstate South Carolina to eliminate existing infestations and prevent new ones from forming.


Our expert technicians use proven, family-safe treatments to remove spiders and the insects they feed on, delivering long-lasting protection and peace of mind.

Our Spider Control Service

We combine expert inspection, precision treatment, and preventive strategies to ensure your property stays spider-free.


Here’s What’s Included:

✅ Comprehensive Inspection

Our trained technicians inspect your property to identify spider species, problem areas, and any contributing pest activity (since spiders often follow other insects indoors).

✅ Web & Egg Sac Removal

We remove visible spider webs, egg sacs, and nesting sites from walls, eaves, corners, and ceilings — indoors and outdoors.

✅ Targeted Treatment

Using professional-grade, EPA-approved products, we treat cracks, crevices, entry points, and baseboards where spiders hide and hunt.

Perimeter Protection

We apply an exterior treatment around your home or business foundation, doors, windows, and eaves to create a protective barrier that keeps spiders and other pests from coming inside.

Ongoing Protection Plans

For year-round defense, Pest Rx offers routine pest control programs that include spider management as part of your general pest protection service.

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Common Spiders in Upstate South Carolina

Our technicians are trained to identify and control all common spiders found in the Upstate region, including:

  • House spiders
  • Wolf spiders
  • Cellar spiders (daddy longlegs)
  • Orb weavers
  • Jumping spiders
  • Black widows (venomous)
  • Brown recluses (venomous)

If you’ve noticed spider activity — especially black or brown spiders in dark areas — call Pest Rx for immediate inspection and treatment.

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Residential & Commercial Spider Control


🏠 Residential Service

Protect your family and home from unwanted spiders with our comprehensive spider treatment plans. We’ll clear webs, eliminate infestations, and create a barrier that keeps them out for good.

🏢 Commercial Service

Whether you manage an office, restaurant, retail space, or warehouse, Pest Rx provides discreet and effective spider control services to keep your property clean, safe, and professional.

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Why Choose Pest Rx?

  • Locally owned & operated in Upstate South Carolina
  • Licensed, experienced pest control specialists
  • Safe, effective, and targeted treatments
  • Honest inspections & detailed service reports
  • Custom plans for homes and businesses
  • 100% satisfaction guaranteed

At Pest Rx, we don’t just eliminate spiders — we address the underlying causes, helping you maintain a pest-free environment all year long.

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Frequently Asked Questions


  • Why do I have spiders in my home?

    Spiders are often attracted by other insects — their food source. If you’re seeing more spiders, it’s likely because there’s another pest issue nearby. Pest Rx targets both spiders and their prey for complete control.

  • Are spiders dangerous?

    Most spiders are harmless, but species like black widows and brown recluses can pose health risks due to their venomous bites. Our technicians are trained to identify and safely eliminate these dangerous species.

  • How can I prevent spiders from coming inside?

    Seal cracks, repair window screens, keep outdoor lights minimal (to reduce insect attraction), and maintain regular pest control service. Routine cleaning and vacuuming also help remove webs and egg sacs.

  • Are your spider treatments safe for kids and pets?

    Yes! All products used by Pest Rx are EPA-approved and applied by licensed professionals with safety in mind. Once treatments dry, your home is completely safe for children and pets.

  • Do I need regular spider treatments?

    For lasting results, we recommend quarterly pest control service. Regular treatments maintain an exterior barrier and keep both spiders and other insects under control year-round.

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Schedule Your Spider Treatment Today

Don’t let spiders take over your property. Contact Pest Rx today for fast, effective spider control in Upstate South Carolina.

📞 Call (864) 419-3766  to schedule your service or request a free inspection.

We proudly serve Greenville, Spartanburg, Anderson, Easley, Simpsonville, and surrounding areas.

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